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NAT2
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For Research Use Only. Not For Clinical Use.
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Hepatocytes, Proximal enterocytes, Paneth cells, Distal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (RPTEC TERT1, RT4, SCLC-21H, SK-BR-3)
Molecular function
Acyltransferase, Transferase
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