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NCLN
Anti-NCLN Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Protein class
Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Theca cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms a complex with NOMO and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome (PubMed:20538592). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (PubMed:32820719). Participates in a large protein complex, which is not related to the gamma-secretase complex (PubMed:15257293).
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