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NCR3
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Protein class
CD markers
Predicted location
Membrane
Single cell type specificity
Group enriched (NK-cells, dendritic cells, T-cells, B-cells)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enhanced (Daudi, HEL, NB-4, U-698)
Interaction
Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
Molecular function
Receptor
More Types Infomation
-
- Species Reactivity: Human
- Type: IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
- Recombinant Mouse Anti-NCR3 Antibody (P30-15) (NEUT-1763CQ)
-
- Species Reactivity: Human
- Type: IgG1, κ
- Application: FC, ELISA, BL
-
- Species Reactivity: Rhesus monkey, Cynomolgus monkey
- Type: Mouse IgG1
- Application: Activ, FuncS
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For Research Use Only. Not For Clinical Use.