Anti-NECTIN4 Recombinant Antibody Products

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Anti-NECTIN4 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs provides globally recognized, top-notch recombinant antibodies for NECTIN4. Leveraging advanced tech and strict quality checks, our antibodies guarantee high specificity, sensitivity, and reliability. Perfect for drug discovery, disease research, and therapy development, we fuel scientific progress.

NECTIN4: A Significant Target for Cancer Treatment

NECTIN4 (Nectin Cell Adhesion Molecule 4) is a transmembrane protein belonging to the nectin family, which plays a crucial role in cell adhesion, migration, and proliferation. It is highly expressed in various cancers, including urothelial carcinoma, making it a promising therapeutic target. NECTIN4 is involved in tumor progression by facilitating cell-cell interactions and immune evasion. Its overexpression correlates with poor prognosis in several malignancies. Targeted therapies, such as antibody-drug conjugates (ADCs) like enfortumab vedotin, have been developed to exploit NECTIN4's high expression in tumors, providing a novel approach for cancer treatment.

Alternative Names

LNIR; PRR4; EDSS1; PVRL4; nectin-4

Background

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Anti-NECTIN4 Recombinant Antibody Products

High-quality anti-NECTIN4 recombinant antibodies are now accessible. They significantly boost research, enabling the creation of new target-specific drugs. These top-performing antibodies are crucial for promoting biomedical research and hastening discoveries in therapeutic development.

Creative Quality Control

We've established a strict quality management system to exceed customer demands for excellent antibody quality. This guarantees product reliability and consistency. As a result, researchers can carry out their studies more confidently and efficiently, obtaining more precise and repeatable outcomes.

Customer Reviews

Excellent

Ja**ry
Human Anti-NECTIN4 Recombinant Antibody (Cat#: TAB-H25)

I recently used the this product in my research, and I'm extremely impressed. It's incredibly versatile, working well in ELISA for quantifying NECTIN4 levels, in Neut to study neutralizing activity. In IF, it clearly stains NECTIN4-expressing cells. For IP, it efficiently pulls down NECTIN4-associated proteins, and in FC, it precisely identifies NECTIN4-positive cell populations. It has truly enhanced the quality and scope of my experiments.

24/Nov/2024

Excellent

Ja**s
Mouse Anti-NECTIN4 Recombinant Antibody (clone N41) (Cat#: HPAB-0034-DJB)

This antibody has been a game-changer in my research. It's highly effective in ELISA, accurately detecting NECTIN4 levels in mouse samples. In IHC, it vividly stains NECTIN4-expressing tissues, enabling clear visualization of its distribution. For FC, it precisely labels NECTIN4-positive cells, facilitating cell sorting and analysis. This antibody has significantly accelerated my study on NECTIN4-related mechanisms in mouse models.

16/May/2024

Excellent

B**ce
Human Anti-NECTIN4 Recombinant Antibody (Cat#: TAB-H25)

The antibody has demonstrated excellent performance in multiple applications. Validated for ELISA, Neut, IF, IP, and FC, it enables accurate detection, functional studies, and cell analysis, making it a valuable asset for NECTIN4 - related research.

28/Jul/2023

Anti-NECTIN4 Recombinant Antibody Production

Boasting profound process optimization expertise, we excel in expression vectors, screening transfected cell lines, and antibody purification. From gene synthesis to antibody production, our all - inclusive services support biomedical researchers. We're dedicated to providing outstanding solutions, simplifying research, and hastening the development of novel therapies.

Featured Anti-NECTIN4 Recombinant Antibody Production Platforms
Fig.4 Milligram-scale recombinant antibody production.

Fig.5 Gram-scale recombinant antibody production.

Anti-NECTIN4 Recombinant Antibody Modalities

Creative Biolabs dedicates itself to supplying researchers with top-notch recombinant antibodies in multiple formats. We offer an array of options like full-length, Fab, scFv, scFv-Fc, and others. This extensive selection guarantees flexibility, allowing our antibodies to be perfectly tailored for diverse applications within the realm of scientific research.

Fig.6 Full Length Anti-NECTIN4 Recombinant Antibody Production and Modalities.

Should you seek more information on our anti - NECTIN4 recombinant antibody products, don't hesitate to contact us. We're enthusiastic about sharing details and exploring collaborative prospects. Our committed team aims to support your research journey, helping you develop novel solutions and achieve success through a productive, win - win partnership.