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This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Protein class

Disease related genes, Human disease related genes

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Syncytiotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, HaCaT, MCF7, OE19, SK-BR-3, T-47d)


Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN. (Microbial infection) Interacts with measles virus Hemagglutinin protein (PubMed:22048310, PubMed:23202587).

Molecular function

Host cell receptor for virus entry, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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