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NEFL
Loading...Anti-NEFL Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Human Anti-NEFL Antibody (clone MS-C2), mRNA (FAMAB-0008WJ-mRNA)
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- Species Reactivity: Human
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- Species Reactivity: Human, Cow, Dog, Horse, Mouse, Pig, Rat
- Type: Mouse IgG1
- Application: IHC-Fr, IHC-P, IB
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- Mouse Anti-NEFL Recombinant Antibody (clone 1H3) (VS3-QX806)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Mouse Anti-NEFL Recombinant Antibody (clone 2G10) (VS3-XY1150)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
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- Human Anti-NEFL Antibody (clone MS-B1), mRNA (FAMAB-0007WJ-mRNA)
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- Species Reactivity: Human
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- Anti-Rat NEFL Immunohistochemistry Kit (VS-0525-XY4780)
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- Species Reactivity: Human, Rat, Porcine, Bovine, Chicken
- Target: NEFL
- Application: IHC
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- Mouse Anti-NEFL Recombinant Antibody (clone 2F8B3) (VS7-0425-WR462)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, FC
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- Anti-NEFL Immunohistochemistry Kit (VS-0525-XY4777)
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- Species Reactivity: Human
- Target: NEFL
- Application: IHC
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- Anti-Mouse NEFL Immunohistochemistry Kit (VS-0525-XY4778)
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- Species Reactivity: Human, Mouse, Rat, Porcine, Bovine, Horse
- Target: NEFL
- Application: IHC
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- Chicken Anti-NEFL Polyclonal IgY (BRD-0822MZ)
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- Species Reactivity: Bovine, Chicken, Horse, Human, Mouse, Pig, Rat
- Type: Chicken antibody
- Application: ICC, IF, IHC, WB
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- Chicken Anti-Neurofilament Light Polyclonal IgY (BRD-1153MZ)
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- Species Reactivity: N/A
- Type: Chicken antibody
- Application: WB, ICC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Rod photoreceptor cells, Distal tubular cells, Excitatory neurons, Enteroendocrine cells, Bipolar cells, Horizontal cells)
Immune cell specificity
Immune cell enriched (memory CD4 T-cell)
Cell line specificity
Group enriched (HEK93, PC-3)
Interaction
Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFH or NEFM; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity). Interacts with ARHGEF28. Interacts with TRIM2.
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