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NEK6

Anti-NEK6 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Protein class

Enzymes, Metabolic proteins, Transporters

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Hofbauer cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HMC-1)

Interaction

Interacts with STAT3 and RPS6KB1 (By similarity). Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus). Interacts with APBB1 (via WW domain). Interacts with ANKRA2, ATF4, ARHGAP33, CDC42, CIR1, PRAM1, PTN, PRDX3, PIN1, RAD26L, RBBP6, RPS7 and TRIP4.

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

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