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NR3C2
Anti-NR3C2 Recombinant Antibody Products
- AbPlus™ Anti-NR3C2 Magnetic Beads (VS-0724-YC351) (VS-0724-YC351)
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- Target: NR3C2
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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- Recombinant Mouse Anti-NR3C2 Antibody (H10E4C9F) (NEUT-1789CQ)
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- Species Reactivity: Human, Mouse, Rat, Chicken, Rabbit, Sheep
- Type: IgG1
- Application: WB, Neut, Flow, ICC/IF, IHC, IHC-P
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For Research Use Only. Not For Clinical Use.
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Astrocytes, Oligodendrocyte precursor cells, Microglial cells)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enhanced (hTERT-RPE1, HUVEC TERT2, Karpas-707, PC-3, RPTEC TERT1, TIME)
Interaction
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.
Molecular function
DNA-binding, Receptor
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