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PALLD
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Basal prostatic cells, Peritubular cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (LHCN-M2)
Interaction
Interacts with EPS8 (By similarity). Interacts with LASP1 (By similarity). Interacts with VASP (By similarity). Interacts with ACTN (PubMed:15147863). Interacts with SORBS2 (PubMed:16125169). Interacts with PFN1 (PubMed:16367745). Interacts with LPP (PubMed:17322171). Interacts with SPIN90 (PubMed:17537434). Interacts with SRC (PubMed:17537434). Interacts with EZR (PubMed:11598191). Interacts with RAI14 (By similarity).
Molecular function
Actin-binding
More Types Infomation
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.