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PDGFD

Anti-PDGFD Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Protein class

RAS pathway related proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Inhibitory neurons, NK-cells, Fibroblasts, Cholangiocytes, Ductal cells, dendritic cells, Microglial cells)

Immune cell specificity

Group enriched (NK-cell, gdT-cell, eosinophil, memory CD8 T-cell, naive CD8 T-cell)

Cell line specificity

Group enriched (ASC diff, HHSteC)

Interaction

Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.

Molecular function

Developmental protein, Growth factor, Mitogen

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