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Anti-PDK3 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Creative Biolabs is a global leader in recombinant antibody development, proud to offer a premier line of anti-PDK3 recombinant antibody products. Our antibodies are engineered for exceptional specificity and performance, providing reliable and high-quality tools for researchers worldwide. We are committed to empowering our global clients with cutting-edge reagents to accelerate their groundbreaking work in biomedical research and drug discovery.
PDK3: A Promising Target for Cancer Therapy
Pyruvate Dehydrogenase Kinase 3 (PDK3) is a crucial mitochondrial enzyme that regulates glucose metabolism by inactivating the pyruvate dehydrogenase complex. Recent research highlights its elevated expression in numerous cancers, where it plays a pivotal role in promoting the metabolic shift necessary for tumor growth and survival. The study of PDK3 is therefore essential, as its inhibition represents a promising therapeutic strategy for developing novel cancer treatments by targeting key metabolic vulnerabilities within tumor cells.
Alternative Names
Pyruvate dehydrogenase kinase 3; CMTX6; GS1-358P8.4; Pyruvate dehydrogenase lipoamide kinase isozyme 3, mitochondria.
Background
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).
Molecular function
Kinase, Transferase
More Types Infomation
Anti-PDK3 rAb Products
Our anti-PDK3 recombinant antibodies are produced using state-of-the-art technology, ensuring superior specificity and affinity. Unlike conventional antibodies, our recombinant products offer enhanced lot-to-lot consistency and minimal background noise, providing researchers with a reliable tool for reproducible results. The superior performance of our antibodies enables more accurate detection and analysis of the PDK3 protein in various applications, from Western Blot to immunohistochemistry.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOR-2646 | Hi-Affi™ Recombinant Rabbit Anti-PDK3 Monoclonal Antibody (DS2646AB) | Mouse, Rat, Predicted to work with: Human | Phage display library screening, IgG | WB, FC |
Table 1. Featured anti-PDK3 recombinant antibody products at Creative Biolabs.
Creative Quality Control
At Creative Biolabs, quality is our top priority. Each batch of anti-PDK3 recombinant antibody undergoes rigorous quality control to meet the highest industry standards. We perform comprehensive validation, including ELISA, Western Blot, and immunofluorescence, to verify its specificity, sensitivity, and functionality. This meticulous process guarantees that every product we deliver performs flawlessly in your specific applications, offering you complete peace of mind.
Customer Reviews
Excellent
Dr. El***e Va**eHi-Affi™ Recombinant Rabbit Anti-PDK3 Monoclonal Antibody (DS2646AB)
I was consistently facing challenges with non-specific binding from other vendors' PDK3 antibodies. The recombinant antibody from Creative Biolabs was a game-changer. Its high specificity and low background noise in my Western Blot experiments have saved me a significant amount of time and resources. I am truly impressed with the quality and reproducibility of the results.
15/May/2024
Excellent
Dr. Ke***i I*oHi-Affi™ Recombinant Rabbit Anti-PDK3 Monoclonal Antibody (DS2646AB)
The anti-PDK3 antibody from Creative Biolabs is an essential tool in my lab's cancer metabolism research. We use it for immunohistochemistry, and the clear, consistent staining results are fantastic. The antibody is incredibly easy to work with, and the robust signal allows us to accurately localize PDK3 in tumor tissues. This product has significantly enhanced our research workflow and data quality.
21/Jun/2024
Excellent
Dr. Ma**a Ro***g**ziHi-Affi™ Recombinant Rabbit Anti-PDK3 Monoclonal Antibody (DS2646AB)
Creative Biolabs' anti-PDK3 recombinant antibody performed exceptionally well in our immunofluorescence studies. The clean signal and high titer were remarkable. We were able to visualize the mitochondrial localization of PDK3 with great clarity. This high-performance antibody is now our go-to for all our research involving PDK3, and we highly recommend it to others.
10/Dec/2024
rAb Production
Our anti-PDK3 recombinant antibodies are manufactured through a carefully optimized and highly controlled production process. Utilizing advanced cell culture and protein purification techniques, we ensure the consistent production of antibodies with high purity and biological activity. This streamlined approach minimizes batch variation, providing researchers with a reliable and uniform product for their critical experiments.
Featured Anti-PDK3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PDK3 recombinant antibody production.
Fig.2 Gram-scale anti-PDK3 recombinant antibody production.
rAb Modalities
Our anti-PDK3 recombinant antibodies are available in various formats and conjugate options, including HRP, FITC, and Biotin, to cater to a wide range of research applications and experimental designs.
Fig.3 Full-length anti-PDK3 recombinant antibody production and modalities.
At Creative Biolabs, we are dedicated to supporting your scientific endeavors with superior quality reagents. Our anti-PDK3 recombinant antibodies represent the pinnacle of our expertise and commitment to excellence. We invite you to explore how our products can accelerate your research into cancer metabolism and therapeutic development. To learn more or discuss your specific research needs, please don't hesitate to contact our expert team. We are ready to assist you.
Related Signaling Pathways
PPAR Signaling Pathway
