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PI3

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.
Protein class

Plasma proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Basal respiratory cells, Club cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Group enriched (EFO-21, HaCaT, OE19, PC-3)

Molecular function

Protease inhibitor, Serine protease inhibitor

More Types Infomation
    • Species Reactivity: Ascaris suum (tested or 100% immunogen sequence identity)
    • Application: ELISA

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