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PLA2G10

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For Research Use Only. Not For Clinical Use.


Background

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids 1, 2. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls.
Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Distal enterocytes, Paneth cells, Intestinal goblet cells, Exocrine glandular cells, Gastric mucus-secreting cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, CAPAN-2, HaCaT, MCF7, OE19, SK-BR-3)

Interaction

Interacts with PLA2R1; this interaction mediates PLA2G10 clearance and inactivation.

Molecular function

Hydrolase

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