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Anti-PPP3R2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Creative Biolabs is your premier source for research-grade anti-PPP3R2 recombinant antibodies to help you explore key questions in reproductive biology. PPP3R2, the testis-specific isoform of the calcineurin regulatory subunit, is believed to be important for sperm function and male fertility. Our high-quality, isoform-specific anti-PPP3R2 recombinant antibodies are essential tools to begin dissecting the specialized functions of calcineurin signaling during spermatogenesis and sperm motility.
PPP3R2: The Testis-Specific Calcineurin B Isoform
Protein Phosphatase 3 Regulatory Subunit B, Beta (PPP3R2) is a highly specialized isoform of the calcineurin B regulatory subunit, which activates calcineurin by binding calcium and targeting the calcineurin catalytic subunit to membranes. The calcineurin alpha-isoform (PPP3R1) is ubiquitously expressed while PPP3R2 expression is testis- and sperm-specific. Like its somatic counterpart, PPP3R2 forms a calcium-activated complex with calcineurin's catalytic subunit, which is enriched in late stages of spermatogenesis and which has been implicated in sperm motility. Given the testis-specific expression of this protein, the calcineurin-regulated pathway containing PPP3R2 is a potential target for reversible male contraceptives with few off-target effects.
Alternative Names
PPP3RL
Background
Protein class
FDA approved drug targets, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Spermatocytes, Early spermatids, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2) (By similarity). Interacts with SPATA33 (via PQIIIT motif) (PubMed:34446558).
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Anti-PPP3R2 rAb Products
In-house engineered with exceptional specificity to the target protein in mind, our anti-PPP3R2 recombinant antibodies have been carefully validated to detect the beta-isoform with no cross-reactivity to the closely homologous and more abundant alpha-isoform (PPP3R1), which is essential to specificity in male reproductive research. Optimized for IHC on testis sections and for Western Blot of sperm lysates, our rAbs can provide crisp, consistent results in your hands.
Table 1. Featured anti-PPP3R2 recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MOB-1627CT | Recombinant Mouse anti-Human PPP3R2 Monoclonal antibody (EML2256) | Human | Mouse IgG | WB |
Customer Reviews
Excellent
B**lyRecombinant Mouse anti-Human PPP3R2 Monoclonal antibody (EML2256)
We trust the consistency of Creative Biolabs' reagents, and the anti-PPP3R2 antibody has been a very important tool for our research. We have been able to reliably use this antibody to provide data on sperm-specific signaling pathways.
13/Jan/2024
rAb Production
At Creative Biolabs, our mission is to provide you with the most advanced reagents to support your reproductive biology research. We use the most cutting-edge recombinant antibody production technologies to ensure our anti-PPP3R2 rAbs are expressed in optimized systems that enable them to recognize unique features of this testis-specific protein.
Featured Anti-PPP3R2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-PPP3R2 recombinant antibody production.
Fig.2 Gram-scale anti-PPP3R2 recombinant antibody production.
rAb Modalities
At Creative Biolabs, we pride ourselves on being innovators and partners in the research community. That's why we offer a range of customizable modalities of our anti-PPP3R2 recombinant antibodies, giving you the flexibility you need to design a wide range of experiments to study this key regulator of male fertility.
Fig.3 Full-length anti-PPP3R2 recombinant antibody production and modalities.
The testis-specific isoform of the calcineurin regulatory subunit PPP3R2 is believed to be important for sperm function and male fertility. With Creative Biolabs' premium anti-PPP3R2 recombinant antibodies, you can begin to dissect the unique functions of calcineurin during spermatogenesis and sperm motility. In addition to thorough validation, our antibodies are optimized for high-quality data generation, and our team is ready to support your research. Contact our specialists today to learn more.
