Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Astrocytes, Inhibitory neurons, Excitatory neurons, Microglial cells)
Immune cell enriched (basophil)
Cell line enhanced (AN3-CA, BJ hTERT+, fHDF/TERT166, U-138 MG, U-87 MG)
Isoform alpha: parallel homodimer or heterodimer and also heterotetramer. Interacts directly with PPP1R12A. Non-covalent dimer of dimer of PRKG1-PRKG1 and PPP1R12A-PPP1R12A. This interaction targets PRKG1 to stress fibers to mediate smooth muscle cell relaxation and vasodilation in responses to rises in cGMP. Isoform beta: antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with IRAG1. Forms a stable complex with ITPR1, IRAG1, and isoform beta of PRKG1. Interacts with TRPC7 (via ankyrin repeat domain). Isoform alpha interacts with RGS2. Interacts with GTF2I.
Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase
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For Research Use Only. Not For Clinical Use.