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For Research Use Only. Not For Clinical Use.


Background

Human CD133 is a penta-span transmembrane glycoprotein. It is a marker of neural, endothelial and hematopoietic stem cells. Its expression is also seen in cancer initiating cells in many tumors including that of brain, prostrate, colon and breast and is, therefore, used widely as a molecular marker to isolate and characterize these cell phenotypes. Targeting CD133 may also enable enhanced delivery of cytotoxic therapies to cancer initiating cells. Further development of CD133 as a diagnostic marker
and/or therapeutic target, requires highly sensitive reagents that exclusively recognize CD133.
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