PSMB8

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins

Intracellular

Low cell type specificity

Low immune cell specificity

Low cell line specificity

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP. Interacts with TAP1. (Microbial infection) Interacts with HIV-1 TAT protein.

Hydrolase, Protease, Threonine protease