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PSMC5
Loading...Anti-PSMC5 Products
- AbPlus™ Anti-PSMC5 Magnetic Beads (VS-0724-YC619) (VS-0724-YC619)
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- Target: PSMC5
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-PSMC5 Immunohistochemistry Kit (VS-0525-XY5795)
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- Species Reactivity: Human
- Target: PSMC5
- Application: IHC
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- Anti-Mouse PSMC5 Immunohistochemistry Kit (VS-0525-XY5796)
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- Species Reactivity: Human, Mouse, Rat
- Target: PSMC5
- Application: IHC
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- Chicken Anti-PSMC5 Polyclonal IgY (BRD-0447MZ)
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- Species Reactivity: Human, Rat
- Type: Chicken antibody
- Application: WB
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- Chicken Anti-PSMC5 Polyclonal IgY (BRD-0924MZ)
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- Species Reactivity: Bovine, Human, Mouse, Pig, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27428775, 27342858). Component of a complex with USP49 and RUVBL1 (PubMed:23824326). Interacts with PRPF19. Interacts with TRIM5 (PubMed:22078707). Interacts with NDC80 (PubMed:9295362, 10409732). Interacts with PAAF1 (PubMed:15831487). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6 (PubMed:26030138).
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