PSMC5

Antibody Magnetic Beads AbPlus Recombinant Antibody Products Formats

Anti-PSMC5 Recombinant Antibody Products

Mouse Anti-PSMC5 Recombinant Antibody (clone 28A7) (MOB-3339z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IP, IF
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Recombinant Mouse anti-Human PSMC5 Monoclonal antibody (36E6) (MOB-1706CT)
- Species Reactivity: Human
- Application: ICC/IF, WB
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Recombinant Rabbit Anti-PSMC5 Antibody (clone R05-2B6) (VS3-FY1209)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
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AbPlus™ Anti-PSMC5 Magnetic Beads (VS-0724-YC619) (VS-0724-YC619)
- Target: PSMC5
- Target Species: Human
- Application: IP, Protein Purification
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Chicken Anti-PSMC5 Polyclonal IgY (BRD-0447MZ)
- Species Reactivity: Human, Rat
- Type: Chicken antibody
- Application: WB
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Chicken Anti-PSMC5 Polyclonal IgY (BRD-0924MZ)
- Species Reactivity: Bovine, Human, Mouse, Pig, Rat
- Type: Chicken antibody
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-PSMC5 Monoclonal Antibody (DS2900AB) (MOR-2900)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, FC, ICC/IF, IHC-P, IP
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For Research Use Only. Not For Clinical Use.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27428775, 27342858). Component of a complex with USP49 and RUVBL1 (PubMed:23824326). Interacts with PRPF19. Interacts with TRIM5 (PubMed:22078707). Interacts with NDC80 (PubMed:9295362, 10409732). Interacts with PAAF1 (PubMed:15831487). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6 (PubMed:26030138).

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