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PTPN4
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- Chicken Anti-PTPN4 Polyclonal IgY (BRD-0464MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Horizontal cells)
Immune cell specificity
Group enriched (gdT-cell, MAIT T-cell, memory CD8 T-cell, NK-cell, naive CD8 T-cell, memory CD4 T-cell, T-reg)
Cell line specificity
Low cell line specificity
Interaction
Interacts with MAPK12 (via C-terminus); this interaction abolishes PTPN4 catalytic autoinhibition and thus activates the phosphatase activity. (Microbial infection) Interacts with attenuated rabies virus protein G; this interaction is required for virally-induced apoptosis.
Molecular function
Hydrolase, Protein phosphatase
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