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PARD3
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.
Protein class
Disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Astrocytes, Oligodendrocyte precursor cells, Microglial cells, Inhibitory neurons)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2. Interacts with ECT2, FBF1 and SIRT2. Interacts (via coiled-coil domain) with FRMD4A (By similarity). Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity). Interacts with SAPCD2 (PubMed:26766442). Interacts with PRKCA (PubMed:27925688). [Isoform 8]: Interacts with PRKCZ.
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.