Enzymes
Intracellular
Cell type enhanced (Suprabasal keratinocytes)
Low immune cell specificity
Low cell line specificity
Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Interacts with GDI1 and with GDI2; negatively regulates RAB10 association with membranes and activation (PubMed:19570034, PubMed:26824392, PubMed:29125462). Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably associates with the exocyst (By similarity). Interacts (GTP-bound form) with MICALCL, MICAL1, MICAL3, EHBP1 and EHBP1L1; at least in case of MICAL1 two molecules of RAB10 can bind to one molecule of MICAL1 (PubMed:27552051). Interacts with TBC1D13 (By similarity). Interacts with SEC16A (By similarity). Interacts with CHM and CHML (PubMed:29125462). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-73 (PubMed:26824392). Interacts (when phosphorylated on Thr-73) with RILPL1 and RILPL2 (PubMed:30398148, PubMed:29125462). Interacts with TBC1D21 (PubMed:28067790).
Hydrolase
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For Research Use Only. Not For Clinical Use.