Intracellular
Cell type enhanced (Enteroendocrine cells, Alveolar cells type 1, Alveolar cells type 2, Pancreatic endocrine cells)
Not detected in immune cells
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, TIME)
Interacts with RIMS1, RIMS2, RPH3A and RPH3AL. The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (By similarity). Interacts with GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (PubMed:29125462). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
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For Research Use Only. Not For Clinical Use.