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RAD23B

Anti-RAD23B ProductsBackground
Anti-RAD23B Products
- APC-A*24:02/Human RAD23B (AANFLLQQNF) MHC Tetramer (MHC-CN0001)
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- Class: Class I
- Antigen: RAD23B
- Antigen Species: Human
- Peptide: AANFLLQQNF
- Conjugate: APC
- PE-A*24:02/Human RAD23B (AANFLLQQNF) MHC Tetramer (MHC-CN0002)
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- Class: Class I
- Antigen: RAD23B
- Antigen Species: Human
- Peptide: AANFLLQQNF
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3 (PubMed:30455355). Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).
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