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RAD51B

Anti-RAD51B Products

Recombinant Mouse anti-Human RAD51B Monoclonal antibody (SBE62C 2F22/7) (MOB-1761CT)
- Species Reactivity: Human
- Application: WB
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Mouse Anti-RAD51B Recombinant Antibody (clone 1h3/13) (FAMAB-1238CQ)
- Species Reactivity: Primate, Human
- Type: Mouse IgG2a
- Application: IP, WB
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Mouse Anti-NHP RAD51B Recombinant Antibody (clone 1 H3/13) (VS-1024-XY432)
- Species Reactivity: Human, Non-human primate
- Type: Mouse IgG2a
- Application: WB
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Recombinant Anti-RAD51B Vesicular Antibody, EV Displayed (VS-0425-YC718) (VS-0425-YC718)
- Species Reactivity: Human
- Target: RAD51B
- Host Animal: Mouse
- Application: ELISA, FC, Cell-uptake
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Hi-Affi™ Recombinant Rabbit Anti-RAD51B Monoclonal Antibody (DS2979AB) (MOR-2979)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

Protein class

Cancer-related genes, Disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Oligodendrocytes, Microglial cells, Oligodendrocyte precursor cells, Astrocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354). The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51 (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354). Interacts with SWSAP1; involved in homologous recombination repair (PubMed:21965664). Interacts with HELQ (PubMed:24005041).

Molecular function

DNA-binding

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