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    RELB

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    For Research Use Only. Not For Clinical Use.


    RELB (RELB Proto-Oncogene, NF-KB Subunit) is a Protein Coding gene. Diseases associated with RELB include Immunodeficiency 53 and Reticuloendotheliosis. Among its related pathways are RANK Signaling in Osteoclasts and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RELA.
    Protein class

    Cancer-related genes, Disease related genes, Plasma proteins, Transcription factors

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Prostatic glandular cells, monocytes, Plasma cells, Basal prostatic cells)

    Immune cell specificity

    Immune cell enhanced (neutrophil)

    Cell line specificity

    Cell line enhanced (Daudi, HDLM-2, U-698)

    Interaction

    Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).

    Molecular function

    Activator, DNA-binding, Repressor

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