Anti-RET Recombinant Antibody Products

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Anti-RET Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers a series of high-quality anti-RET recombinant antibodies to advance global customers’ research projects. Based on our cutting-edge antibody engineering platform, these antibodies exhibit excellent sensitivity and excellent specificity, making them the optimal selection for diverse research application.

RET: A Versatile Immunotherapeutic Target

The RET (REarranged during Transfection) proto-oncogene is constitutively activated through structural reconfiguration, wherein its 3' tyrosine kinase domain undergoes genetic recombination with the 5' regions of partner genes encoding dimerization motifs, such as coiled-coil domains. Such oncogenic fusions have been identified across multiple malignancies, including carcinomas of the thyroid, lung, colorectal tissue, breast, and salivary glands. Functional genetic analyses reveal RET's indispensable contributions to enteric nervous system formation, renal organogenesis, and germ cell maturation. Ongoing investigations into RET-mediated signaling pathways continue to yield critical insights, bridging molecular oncology with fundamental studies of neural development and tissue morphogenesis.

Alternative Names

RET proto-oncogene; ret proto-oncogene; Ret; PTC; RET51; RET9; c-Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; RET-ELE1.

Background

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.

Anti-RET rAb Products

Creative Biolabs delivers engineered recombinant antibodies targeting RET, meticulously optimized for high-affinity binding and molecular specificity. These adaptable formats serve multifaceted applications spanning immunological studies, oncological investigations, and drug development pipelines. Production workflows incorporate rigorous quality control systems, reinforced by multidimensional validation protocols encompassing epitope mapping and functional characterization. By synthesizing molecular engineering innovations with standardized quality frameworks, the platform generates antibody reagents with enhanced target discrimination, binding stability, and methodological reproducibility—ensuring experimental reproducibility across fundamental and translational research applications.

Table 1. Featured anti-RET recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs employs multistage quality assurance protocols to engineer anti-RET recombinant antibodies with high specificity and robust binding kinetics. Rigorous analytical validation ensures consistent functional performance of these biologics across diverse experimental systems, supported by standardized testing methodologies to confirm reproducibility in research applications.

Customer Reviews

Excellent

Vi***a
Mouse Anti-RET Recombinant Antibody (clone 8D10C9) (VS3-XY1369)

In our IHC investigations, the anti-RET antibody we obtained behaved precisely as predicted and was of excellent quality. a consistent reagent for our investigation on cancer.

11/Jun/2023

Excellent

Ri***y
Mouse Anti-RET Recombinant Antibody (ZG-065R) (ZG-065R)

Creative Biolabs offers a very selective anti-RET antibody together with first-rate customer service. Working with it was simple and produced consistent, reliable findings in our Western blotting tests.

25/Sep/2024

Excellent

Mi***n
Rabbit Anti-RET Recombinant Antibody (VS3-CJ479) (VS3-CJ479)

We like Creative Biolabs' given versatility in antibody forms. The tailored antibody rapidly advanced our study on RET signaling pathways by exactly matching our particular experimental setting.

13/Nov/2024

rAb Production

Creative Biolabs provides a reliable global supply of high-quality anti-RET recombinant antibodies, meticulously developed through cutting-edge recombinant technology for research applications.

Featured Anti-RET Recombinant Antibody Production Platforms
Fig.4 Milligram-scale anti-RET recombinant antibody production.

Fig.5 Gram-scale anti-RET recombinant antibody production.

rAb Modalities

Creative Biolabs offers high-quality, customisable anti-RET recombinant antibodies tailored to meet specific research needs. These antibodies are offered in various forms and are meticulously tailored to meet the specific needs of local, national, and global research communities.

Fig.6 Full-length anti-RET recombinant antibody production and modalities.

RET-Targeted Drug Information

Table 2. Public drug targeting RET.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

With extensive expertise in the antibody development sector, Creative Biolabs boasts years of exceptional experience in both antibody engineering and production. The performance of these antibodies is outstanding across a range of research applications. If you have an interest in our RET recombinant antibodies, we invite you to reach out to us for exclusive pricing information.

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