REV3L

Formats

Anti-REV3L Recombinant Antibody Products

Recombinant Anti-Human REV3L Antibody (MOB-3418z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Dot, FuncS
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Recombinant Anti-Human REV3L Antibody Fab Fragment (MOB-3418z-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FacS, FuncS
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Recombinant Anti-Human REV3L Antibody scFv Fragment (MOB-3418z-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
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For Research Use Only. Not For Clinical Use.

Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis

Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Endometrial stromal cells, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.

Molecular function

DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

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