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RNASE1

Anti-RNASE1 Products

Mouse Anti-RNASE1 Recombinant Antibody (clone 4A11) (MOB-1795z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA
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Mouse Anti-RNASE1 Recombinant Soluble TCR (clone KRN) (scTCR-1033YC-S(P))
- Species Reactivity: Cattle
- Epitope: PVNTFVHESLADVQA
- MHC: H2-IAᵏ
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Recombinant Mouse Anti-RNASE1 Soluble TCR (KRN) (ZIP-Fos/ZIP-Jun) (VS-0622-YF2322)
- Species Reactivity: Cattle
- Epitope: PVNTFVHESLADVQA
- MHC: H2-IAᵏ
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Recombinant Mouse Anti-RNASE1 Soluble TCR (KRN) (C-Cys) (VS-0622-YF5030)
- Species Reactivity: Cattle
- Epitope: PVNTFVHESLADVQA
- MHC: H2-IAᵏ
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Recombinant Mouse Anti-RNASE1 Soluble TCR (KRN) (KIH) (VS-0622-YF7738)
- Species Reactivity: Cattle
- Epitope: PVNTFVHESLADVQA
- MHC: H2-IAᵏ
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Recombinant Anti-Bovine RNASE1 VHH Single Domain Antibody (PNBL-008) (PNBL-008)
- Derivation: Llama
- Species Reactivity: Bovine
- Type: Llama VHH
- Application: WB, FuncS
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Recombinant Anti-Bovine RNASE1 VHH Single Domain Antibody (PNBL-101)
- Derivation: Llama
- Species Reactivity: Bovine
- Type: Llama VHH
- Application: WB, FuncS
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Camelid Anti-RNASE1 Recombinant Antibody (clone cAb-RN05) (EPAF-0159CQ)
- Species Reactivity: Bovine
- Type: Camelid VHH
- Application: ELISA
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Protein class

Enzymes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Hofbauer cells, Alveolar cells type 1, Adipocytes, Gastric mucus-secreting cells, Alveolar cells type 2, Intestinal goblet cells, Hepatic stellate cells, Macrophages)

Immune cell specificity

Immune cell enhanced (myeloid DC, classical monocyte)

Cell line specificity

Cell line enhanced (HUVEC TERT2, OE19, RT4, TIME)

Interaction

Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.

Molecular function

Endonuclease, Hydrolase, Lyase, Nuclease

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