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    RNASE3

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria.
    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Early spermatids, Late spermatids, Erythroid cells, Kupffer cells, Rod photoreceptor cells, Macrophages)

    Immune cell specificity

    Immune cell enriched (eosinophil)

    Cell line specificity

    Cell line enhanced (HL-60, NB-4, THP-1, U-937)

    Interaction

    Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.

    Molecular function

    Antibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease

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