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Anti-S1PR4 Recombinant Antibody Products

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Anti-S1PR4 Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs, drawing on extensive expertise in antibody engineering, presents an extensive range of recombinant anti-S1PR4 antibodies. Tailored for researchers worldwide, our carefully developed antibodies demonstrate outstanding specificity, affinity, and consistent quality across batches, enhancing your studies on the vital role of S1PR4 in immunology, inflammation, and more. Discover our varied offerings and propel your scientific advancements.

S1PR4: A Key Modulator of Immune Cell Function

S1PR4, or sphingosine-1-phosphate receptor 4, is a G protein-coupled receptor that binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and plays a significant role in the immune system, particularly within lymphoid and hematopoietic tissues as well as the lungs. Upon activation by S1P, S1PR4 couples to Gi and G12/13 proteins, influencing various cellular processes such as cell shape, motility, and immune cell function, including activation, differentiation, and potentially trafficking. Recent research suggests S1PR4's involvement in modulating innate immune cell activation and cytokine production, impacting inflammatory responses and even tumor progression, making it a potential therapeutic target for immune-related diseases and cancer.

Alternative Names

Sphingosine-1-phosphate receptor 4; S1P receptor 4; EDG6; LPC1; S1P4; SLP4.

Background

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants.

Protein class

G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (NK-cells, dendritic cells, T-cells, B-cells, monocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HDLM-2, HL-60, NB-4, REH, U-937)

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

Anti-S1PR4 rAb Products

Creative Biolabs' cutting-edge recombinant anti-S1PR4 antibodies are engineered for superior performance in your research. Unlike traditional antibodies, our recombinant technology ensures unparalleled lot-to-lot consistency and eliminates batch variability, providing reliable and reproducible results. Benefit from high specificity, minimizing off-target binding and ensuring accurate target identification. Choose from a variety of formats and modifications tailored to diverse applications, empowering your studies with confidence and precision.

Table 1. Featured anti-S1PR4 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
ZG-0670F Mouse Anti-S1PR4 Recombinant Antibody (clone 1) Human Mouse IgG1 WB, FC
TAB-383CT Human Anti-S1PR4 Recombinant Antibody (TAB-383CT) Human Human IgG2 ELISA, WB
TAB-383CT-S(P) Human Anti-S1PR4 Recombinant Antibody; scFv Fragment Human Human scFv ELISA, WB

Creative Quality Control

At Creative Biolabs, rigorous quality control is paramount. Each anti-S1PR4 recombinant antibody undergoes a comprehensive suite of tests, including ELISA, SDS-PAGE, and flow cytometry, to verify its identity, purity, and binding activity. We employ advanced techniques to ensure optimal performance and validate our antibodies across multiple applications. This commitment to quality guarantees that our products consistently meet the highest standards, delivering reliable and trustworthy results for your critical experiments.

Fig.1 WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-SIPR4 antibody
(Cat# ZG-0670F, Creative Biolabs).

Fig.2 IF analysis. (Creative Biolabs Original)Fig.2 IF analysis of anti-SIPR4 antibody
(Cat# ZG-0670F, Creative Biolabs).

Customer Reviews

Excellent
Ju***a
Mouse Anti-S1PR4 Recombinant Antibody (clone 1) (ZG-0670F)
I've used Creative Biolabs' anti-S1PR4 antibody in my flow cytometry experiments, and the results are outstanding. The signal-to-noise ratio is excellent, making it easy to distinguish S1PR4-positive cells. The antibody worked perfectly right out of the box, saving me valuable time and resources. I'm very impressed with the overall user experience.
24/Feb/2023
Excellent
Ja***k
Human Anti-S1PR4 Recombinant Antibody (TAB-383CT) (TAB-383CT)
I've been consistently impressed with the performance of Creative Biolabs' anti-S1PR4 antibodies. The specificity is excellent, and I've seen very clean results in my IHC experiments. It is a reliable product!
12/Mar/2024
Excellent
Ho***y
Mouse Anti-S1PR4 Recombinant Antibody (clone 1) (ZG-0670F)
The lot-to-lot consistency of these antibodies is a game-changer. It has significantly improved the reproducibility of my research, and I no longer have to worry about variability between batches. Highly recommended!
27/Sep/2024

rAb Production

The production of our recombinant anti-S1PR4 antibodies involves state-of-the-art facilities and optimized protocols. We utilize advanced recombinant techniques to ensure high yields and exceptional purity. Our experienced team carefully monitors each step, from gene synthesis to final product formulation, to maintain the highest quality standards.

Featured Anti-S1PR4 Recombinant Antibody Production PlatformsFig.3 Milligram-scale. (Creative Biolabs Original)
Fig.3 Milligram-scale anti-S1PR4 recombinant antibody production.

Fig.4 Gram-scale. (Creative Biolabs Original)Fig.4 Gram-scale anti-S1PR4 recombinant antibody production.

rAb Modalities

Creative Biolabs provides high-quality, custom anti-S1PR4 recombinant antibodies that are precisely tailored to satisfy the various demands of researchers around the world.

Fig.5 S1PR4 antibody production and modalities. (Creative Biolabs Original)Fig.5 Full-length anti-S1PR4 recombinant antibody production and modalities.

S1PR-Targeted Drug Information-1

Table 2. Public drug targeting S1PR.

Company Research phase Classification Condition
ALS Therapy Development Inst (ALS TDI) (ALS Therapy Development Institute)
ALS Therapy Development Institute
First Affiliated Hosp Fujian Med Univ
Indiana University
Mitsubishi Tanabe Pharma (Originator)
Novartis
Taito (Originator)
Launched - 2010 Prodrugs Amyotrophic lateral sclerosis
Asthma
Chronic inflammatory demyelinating polyneuropathy
Immunosuppression
Multiple sclerosis
Multiple sclerosis, primary progressive
Multiple sclerosis, relapsing-remitting
Optic neuritis
Polyneuropathy, demyelinating
Renal Disorders
Rett syndrome
Schizophrenia
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19)
Transplant rejection
Transplant rejection, kidney
Lpath (Originator)
Lpath Therapeutics (Lpath)
Merck Serono
Pfizer
Phase II Cancer Immunotherapy
Humanized Monoclonal Antibodies
Cancer
Cancer, kidney (renal cell carcinoma)
Heart failure
Retinal detachment
Wet macular degeneration (exudative)
VYNE Therapeutics (Originator) Phase I/II Fixed-Dose Combinations
Prodrugs
Atopic dermatitis
Institute of Materia Medica of Beijing (Originator) Phase I Prodrugs Psoriasis
Washington University (Originator) Phase I Carbon-Radiolabeled Products
Nuclear Imaging Agents
Atherosclerosis
Injury, vascular
Multiple sclerosis
Neurodegeneration
Neuroinflammation
Bristol-Myers Squibb (Originator) Phase I Prodrugs Autoimmune disease
Rheumatoid arthritis
Daiichi Sankyo (Originator) Discontinued Prodrugs Immunological Disorders
Multiple sclerosis
Washington University (Originator) Preclinical Fluorine-Radiolabeled Products
Nuclear Imaging Agents
Neuroinflammation
Capital Medical University (CMU) (Originator)
Ocean University of China (Originator)
Preclinical Chemosensitizers Cancer, colorectal
Washington University (Originator) Preclinical Fluorine-Radiolabeled Products
Nuclear Imaging Agents
Neurological Disorders
Washington University (Originator) Preclinical Fluorine-Radiolabeled Products
Nuclear Imaging Agents
Neurological Disorders

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

S1PR-Targeted Drug Information-2

Table 3. Drug targeting S1PR (under development).

Company Research phase Classification Condition
Autobahn Therapeutics (Originator) Biological Testing Prodrugs Adrenoleukodystrophy, X-linked
Multiple sclerosis
Autobahn Therapeutics (Originator) Biological Testing Prodrugs Adrenoleukodystrophy, X-linked
Multiple sclerosis
Novartis (Originator) Biological Testing Deuterated Compounds Inflammation, lung
Korea Institute of Science & Technology (Originator) Biological Testing Selenium Compounds Multiple sclerosis
Korea Institute of Science & Technology (Originator) Biological Testing Prodrugs
Selenium Compounds
Multiple sclerosis
Korea Institute of Science & Technology (Originator) Biological Testing Selenium Compounds Multiple sclerosis
Beijing Shenlantai Pharmaceutical Technology (Originator) Biological Testing Chemosensitizers Cancer
University of California (Originator) Biological Testing Pegylated Drugs
Prodrugs
Cancer
Multiple sclerosis
Celgene Biological Testing Cocrystals Multiple sclerosis
Psoriasis

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is committed to providing researchers with the tools they need to advance scientific understanding. With our extensive experience and dedication to quality, we are confident that our anti-S1PR4 recombinant antibodies will be valuable assets in your research endeavors. For more information about our products and services, please don't hesitate to contact us.

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