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SAMHD1
Anti-SAMHD1 Recombinant Antibody Products
- Mouse Anti-NHP SAMHD1 Recombinant Antibody (clone OTI3F5) (VS-1024-XY461)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG2b
- Application: WB, IHC, IF, FC
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For Research Use Only. Not For Clinical Use.
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Macrophages, Kupffer cells, monocytes, dendritic cells, Endometrial ciliated cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (ASC diff, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
Interaction
Homodimer; in absence of GTP and dNTP (PubMed:24141705, PubMed:24217394, PubMed:28229507, PubMed:25760601). Homotetramer; in GTP- and dNTP-bound form (PubMed:23601106, PubMed:26101257, PubMed:24141705, PubMed:24217394, PubMed:28229507, PubMed:26294762, PubMed:26431200, PubMed:25288794, PubMed:25267621, PubMed:25760601). Interacts with MRE11; leading to stimulate the exonuclease activity of MRE11 (PubMed:28834754, PubMed:29670289). Interacts with RBBP8/CtIP (PubMed:28834754). Interacts (via its C-terminus) with CD81. (Microbial infection) Interacts with HIV-2 viral protein Vpx; promoting interaction with a E3 ubiquitin-protein ligase complex containing DCAF1, leading to subsequent ubiquitination and degradation of SAMHD1.
Molecular function
Allosteric enzyme, Hydrolase
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