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SIGLEC11

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Group enriched (Granulosa cells, Theca cells)

Immune cell specificity

Immune cell enhanced (eosinophil, non-classical monocyte)

Cell line specificity

Cell line enriched (HEL)

Interaction

Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.

More Types Infomation

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