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SLAMF1
Loading...Anti-SLAMF1 Products
- Recombinant Rat Anti-Slamf1 Antibody (TC15-12F12.2) (NEUT-1972CQ)
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- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, Costim, IP, BL
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- Recombinant Rat Anti-SLAMF1 Antibody (9D1) (FN-176CQ)
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- Species Reactivity: Fish, Mouse
- Type: Rat IgG1
- Application: FC, FuncS, Neut, IHC, IF
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- Human Anti-SLAMF1 Recombinant Antibody (VS-0723-WK117) (VS-0723-WK117)
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
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- Species Reactivity: Human
- Target: SLAMF1
- Host Animal: Human
- Application: ELISA, FC, Cell-uptake
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- Anti-SLAMF1 Immunohistochemistry Kit (VS-0525-XY6618)
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- Species Reactivity: Human
- Target: SLAMF1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Enables several functions, including SH2 domain binding activity; identical protein binding activity; and virus receptor activity. Involved in several processes, including negative regulation of CD40 signaling pathway; negative regulation of cytokine production; and positive regulation of MAPK cascade. Located in extracellular exosome. Is active in plasma membrane.
Protein class
CD markers
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, T-cells, B-cells, monocytes, Melanocytes)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enriched (HDLM-2)
Interaction
Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:11313386, PubMed:11806999, PubMed:12458214). Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (PubMed:11313386, PubMed:12458214). Interacts with MAP4K1 (PubMed:20231852). Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:20818396). (Microbial infection) Interacts with measles hemagglutinin protein.
Molecular function
Host cell receptor for virus entry, Receptor
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