Anti-SLC7A9 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your nephrology and metabolic disease research expert. We offer high-quality, highly specific anti-SLC7A9 recombinant antibodies. SLC7A9 is a subunit of the renal amino acid transporter b(0,+) and is required for the reabsorption of cystine and other amino acids from urine. Our validated antibodies are valuable tools for understanding the molecular mechanisms of cystinuria and for identifying new treatments for this genetic disorder.

SLC7A9: The Light Subunit of the Renal Cystine Transporter

Solute Carrier Family 7 Member 9 (SLC7A9), also known as rBAT, is a multi-pass transmembrane protein that acts as the light subunit of the b(0,+) amino acid transporter. It forms a disulfide-linked heterodimer with the heavy subunit SLC3A1 (rBAT) to form the functional b(0,+) amino acid transporter. The b(0,+) complex is localized to the apical membrane of proximal tubule cells, where it functions to reabsorb cystine, ornithine, lysine and arginine from the glomerular filtrate. Loss of function mutations in SLC7A9 or its associated protein SLC3A1 lead to a decreased capacity to reabsorb these amino acids, leading to very high levels in the urine, the formation of painful cystine kidney stones and chronic kidney disease. Collectively, these symptoms are known as cystinuria.

Alternative Names

BAT1; CSNU3

Background

This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]

Anti-SLC7A9 rAb Products

Our anti-SLC7A9 recombinant antibodies are highly specific and optimized for performance. They have been validated to recognize the SLC7A9 subunit of the b(0,+) transporter in both kidney tissue and cellular models. Optimized for applications such as IHC to study transporter localization, and Western Blot to monitor expression, our rAbs are the perfect tool to provide clear, reproducible data for your cystinuria research.

Table 1. Featured anti-SLC7A9 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has access to state-of-the-art antibody production platforms, which allows us to offer products to support niche research areas such as renal transport. Our anti-SLC7A9 recombinant antibodies are expressed in highly optimized systems to ensure that the antibodies are specific for the native protein in its dimeric complex and thus a specific and active research tool.

Featured Anti-SLC7A9 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-SLC7A9 recombinant antibody production.

Fig.2 Gram-scale anti-SLC7A9 recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about facilitating scientific discovery by providing flexible antibody solutions to the research community. We have a wide range of modalities available and our anti-SLC7A9 recombinant antibodies are available in a variety of customizable formats to support different experimental requirements. This means that researchers from around the world can utilize Creative Biolabs' products to better understand the molecular basis of inherited kidney stone disease.

Fig.3 Full-length anti-SLC7A9 recombinant antibody production and modalities.

Study the mechanisms of cystinuria using Creative Biolabs' high-quality, highly specific anti-SLC7A9 recombinant antibodies. Our product portfolio offers the robust validation and lot-to-lot consistency you need to study this crucial amino acid transporter. Choose Creative Biolabs and let us provide your research with a reliable foundation. Contact our scientific team today.