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SOCS3
Anti-SOCS3 Recombinant Antibody Products
- Mouse Anti-SOCS3 Recombinant Antibody (clone 3A10A12) (VS7-0425-WR902)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC
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- Mouse Anti-SOCS3 Recombinant Antibody (clone 5E12E7F1) (VS7-0425-WR903)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, ICC, FC
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- Mouse Anti-SOCS3 Recombinant Antibody (VS7-0425-WR904) (VS7-0425-WR904)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC-P, IF
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Protein class
Disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Skeletal myocytes, Fibroblasts, Smooth muscle cells, Langerhans cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (HDLM-2, HSkMC, U-266/70)
Interaction
Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain (PubMed:10421843). Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors (PubMed:12027890, PubMed:14559241). Interaction with CSNK1E stabilizes SOCS3 protein (PubMed:15070676). Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3 (PubMed:15601820). Interacts with CUL5, RNF7, ELOB and ELOC (PubMed:15601820). Interacts with CUL2 (PubMed:15601820). Interacts with FGFR3 (PubMed:16410555). Interacts with INSR (By similarity). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2 (By similarity). Interacts with NOD2 (via CARD domain); the interaction promotes NOD2 degradation (PubMed:23019338).
Molecular function
Signal transduction inhibitor
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Related Signaling Pathways
TNF Signaling Pathway