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SOX5

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Protein class

Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)

Immune cell specificity

Group enriched (memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced (AF22, Daudi, HDLM-2, K-562, WM-115)

Interaction

Forms homodimers and heterodimers with SOX6.

Molecular function

Activator, DNA-binding

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