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SOX9
Loading...Anti-SOX9 Products
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC/IF, IP
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- Rabbit Anti-SOX9 Recombinant Antibody (clone AFY0077) (MOR-0106-FY)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ICC, IHC, WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Squamous epithelial cells, Cholangiocytes, Basal squamous epithelial cells, Astrocytes, Gastric mucus-secreting cells, Muller glia cells, Breast glandular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AN3-CA, Hep G2, OE19, U-251 MG)
Interaction
Homodimer; homodimerization is required for activity (By similarity). Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (By similarity). Interacts with DDRGK1 (PubMed:28263186). Interacts with EP300/p300 (PubMed:12732631). Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (By similarity).
Molecular function
Activator, DNA-binding
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway