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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hofbauer cells)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (EFO-21, Hep G2, RPTEC TERT1)
Interaction
Ligand for integrin alpha-V/beta-3.
Molecular function
Cytokine
More Types Infomation