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SPP1

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Hofbauer cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (EFO-21, Hep G2, RPTEC TERT1)

Interaction

Ligand for integrin alpha-V/beta-3.

Molecular function

Cytokine

More Types Infomation
More Infomation

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For Research Use Only. Not For Clinical Use.

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