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SUMO2
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with SAE2 and UBE2I. Interacts with ZNF451. Identified in a complex with ZNF451 and UBE2I/UBC9, where one ZNF451 interacts with one UBE2I/UBC9 and two SUMO2 chains, one bound to the UBE2I/UBC9 active site and the other to another region of the same UBE2I/UBC9 molecule. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with MTA1 (PubMed:21965678). Interacts with HINT1 (By similarity). Interacts with GCNA (via SIM domains); this interaction allows the GCNA recruitment to DPCs sites (PubMed:30914427). (Microbial infection) Interacts with Epstein-barr virus BGLF4.
More Types Infomation
- Goat anti-Human SUMO-2 Antibody (MOB-0414ZL)
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- Species Reactivity: Mouse, Rat, Human
- Application: WB, IP, IF, ELISA
- Recombinant Anti-Human SUMO2 Antibody (MOB-604NL)
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- Species Reactivity: Human
- Application: WB, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P, ICC
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- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse IgG2b
- Application: WB, ICC
- Adhiron scaffold protein anti-Yeast SUM02 (SAD-L257)
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- Scaffold Name: Adhiron
- Target: SUM02
- Species Reactivity: Yeast
- Derivation: Phage display
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For Research Use Only. Not For Clinical Use.