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SYNJ2

Anti-SYNJ2 Products

Recombinant Mouse anti-Human SYNJ2 Monoclonal antibody (EML849) (MOB-1394CT)
- Species Reactivity: Human
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-SYNJ2 Monoclonal Antibody (DS3481AB) (MOR-3481)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IP, WB
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For Research Use Only. Not For Clinical Use.

Background

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.

Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Pancreatic endocrine cells, Glandular and luminal cells, Excitatory neurons)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (GAMG, TIME)

Interaction

Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

Molecular function

Hydrolase, RNA-binding

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