Anti-TAP1 Products

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For Research Use Only. Not For Clinical Use.

Unlock the secrets of the immune system with Creative Biolabs' top-tier anti-TAP1 recombinant antibodies. Dive into the depths of immunology with antibodies targeting Transporter associated with Antigen Processing 1 (TAP1), a key player in antigen presentation and immune surveillance. With Creative Biolabs, researchers gain access to superior antibodies that will help reveal the intricacies of the tumor immune escape, viral infections, and autoimmune pathogenesis.

TAP1: The Gatekeeper of Peptide Presentation to the Immune System

Transporter associated with Antigen Processing 1 (TAP1) plays a key role in the major histocompatibility complex (MHC) class I antigen presentation pathway. TAP1 assembles with its partner TAP2, to form a heterodimeric transporter in the membrane of the endoplasmic reticulum. This active transporter translocates the cytosolic peptides generated from viral or tumor antigens into the lumen of the ER, where they will be loaded on MHC class I molecules and transported to the cell surface for presentation to cytotoxic T lymphocytes (CTLs), to start the chain of an immune response. TAP1 downregulation is one of the common ways for tumor cells to evade the immune response.

Alternative Names

APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*0102N; antigen peptide transporter 1; ABC transporter

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

Anti-TAP1 rAb Products

Creative Biolabs' anti-TAP1 recombinant antibodies are optimized for unmatched specificity and superior performance. They are extensively validated for reliable detection of the TAP1 protein in complex cellular lysates and tissue samples. Produced with high affinity and minimal background, our rAbs are fine-tuned for rigorous applications, such as immunoprecipitation and Western Blot, to ensure you get the best possible results every time.

Table 1. Featured anti-TAP1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is proud to be an innovative force for the immunology research community, harnessing advanced production technologies. To help you unlock the secrets of the immune system, Creative Biolabs' anti-TAP1 recombinant antibodies are produced in optimized mammalian cell lines.

Featured Anti-TAP1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-TAP1 recombinant antibody production.

Fig.2 Gram-scale anti-TAP1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering researchers with flexible and innovative immune research solutions. Our anti-TAP1 recombinant antibodies are available in a variety of customizable modalities, from full-length IgGs for cellular assays to smaller fragments for specific applications. Creative Biolabs serves researchers around the world by tailoring our products to your unique scientific needs.

Fig.3 Full-length anti-TAP1 recombinant antibody production and modalities.

Decode the complex interplay between immune surveillance and evasion with Creative Biolabs' top-tier anti-TAP1 recombinant antibodies. Backed by unparalleled specificity, extensive validation, and consistent performance, our portfolio will provide you with the confidence to pursue even the most complex immunological questions. Partner with Creative Biolabs for reliable research tools that help advance discovery. Contact our experts today.