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TAP1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BEWO)
Interaction
Heterodimer of TAP1 and TAP2 (TAP1-TAP2) (PubMed:1538751). A component of the peptide loading complex (PLC), interacts via TAPBP with MHCI heterodimer; this interaction mediates peptide-MHCI assembly (PubMed:26611325). Recruits TAPBP in a 1:1 stoichiometry (PubMed:22638925). Interacts with classical MHCI such as HLA-A*02-B2M; this interaction is obligatory for the loading of peptide epitopes (PubMed:8805302, PubMed:8630735). Interacts with non-classical MHCI molecules including HLA-E-B2M and HLA-F-B2M as well as PLC component CALR before the peptide loading (PubMed:9427624, PubMed:10605026). Interacts with PSMB5 and PSMB8 (PubMed:15488952). (Microbial infection) Interacts with Epstein-Barr virus BNLF2a. (Microbial infection) Interacts with herpes simplex virus US12/ICP47. (Microbial infection) Interacts with adenovirus E3-19K glycoprotein, which binds TAP1-TAP2 and acts as a TAPBP inhibitor, preventing TAP1-TAP2 association with MHCI.
Molecular function
Translocase
More Types Infomation
Related Diseases
Primary Immunodeficiency
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- Species Reactivity: Human
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, ICC, IF, IP
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IF, WB, IP
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For Research Use Only. Not For Clinical Use.