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TDGF1
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Distal tubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEL, NTERA-2, SuSa)
Interaction
Interacts with the activin type-1 receptor ACVR1B.
Molecular function
Growth factor
More Types Infomation
- Mouse Anti-TDGF1 Recombinant Antibody (clone CBL032) (NEUT-1990CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
- Mouse Anti-TDGF1 Recombinant Antibody (clone 6M17) (NEUT-1989CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
- Mouse Anti-Tdgf1 Recombinant Antibody (clone CBL357) (NEUT-1992CQ)
-
- Species Reactivity: Mouse
- Type: Mouse IgG2b
- Application: Block, CyTOF, FC, ICC
- Mouse Anti-TDGF1 Recombinant Antibody (clone CBL310) (NEUT-1991CQ)
-
- Species Reactivity: Human, Primate
- Type: Mouse IgG1
- Application: Block, ICC, ELISA
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IP, WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB, IHC, IP, IF, FC
- Recombinant Anti-Human TDGF1 Antibody scFv Fragment (MOB-2436z-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IF, FuncS
- Recombinant Anti-Human TDGF1 Antibody Fab Fragment (MOB-2436z-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, WB, FuncS
- Human Anti-TDGF1 Recombinant Antibody (HPAB-1431-FY) (HPAB-1431-FY)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: Inhib
- Anti-cripto (clone huB3F6)-SPDB-DM4 ADC (ADC-031LZY)
-
- Target: cripto
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Human Anti-TDGF1 Recombinant Antibody; Fab Fragment (HPAB-1431-FY-F(E)) (HPAB-1431-FY-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Inhib
- Chicken Anti-TDGF1 Polyclonal IgY (BRD-0579MZ)
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- Species Reactivity: Human, Cow
- Type: Chicken antibody
- Application: WB
-
- Target: Cripto protein
- Linker: Disulfide-linker
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Human Anti-TDGF1 Recombinant Antibody; scFv Fragment (HPAB-1431-FY-S(P)) (HPAB-1431-FY-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Inhib
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For Research Use Only. Not For Clinical Use.