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TGFB1I1
Anti-TGFB1I1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Sertoli cells, Peritubular cells, Smooth muscle cells, Leydig cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (hTERT-RPE1)
Interaction
Homooligomer (By similarity). Interacts with PPARG (PubMed:15687259). Interacts with TRAF4 (PubMed:16330715). Interacts with CRIP2 (By similarity). Interacts with HSPB1 (By similarity). Interacts with ILK (By similarity). Interacts with LIMS1 and LIMS2 (By similarity). Interacts with NCK2 (By similarity). Interacts with NUDT16L1 (By similarity). Interacts with PAK (By similarity). Interacts with PTPN12 (By similarity). Interacts with TCF3 (By similarity). Interacts with TCF7L2 (By similarity). Interacts with VCL (By similarity). Interacts (via LD motif 3) with GIT1 (PubMed:12153727). Also interacts with GIT2 (By similarity). Forms a complex with ARHGEF7 (By similarity). Interacts with AR/androgen receptor in a ligand-dependent manner (PubMed:10075738, PubMed:12714604, PubMed:12700349, PubMed:17202804). Interacts with CSK (PubMed:10838081, PubMed:17233630). Interacts with PTK2/FAK1 and PTK2B/PYK2 (PubMed:9422762, PubMed:9756887, PubMed:9664039, PubMed:10838081, PubMed:11311131, PubMed:11856738, PubMed:17202804). Interacts with SLC6A3 and SLC6A4 (PubMed:12177201, PubMed:16803896). Interacts with NR3C1 (PubMed:15211577). Interacts with SMAD3 (PubMed:15561701). Interacts with MAPK15 (PubMed:16624805). Interacts with SRC (PubMed:17202804). Interacts with LYN (PubMed:17233630). Interacts with talin (PubMed:9664039). Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity (PubMed:23145173). Interacts with PARVA (By similarity). Interacts with PXN (By similarity).
Molecular function
Activator
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