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    Anti-TNF Recombinant Antibody Products

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    For Research Use Only. Not For Clinical Use.


    Leading the way in the production of superior anti-TNF recombinant antibody products, Creative Biolabs supports pharmaceutical firms and researchers globally. Our cutting-edge solutions offer unparalleled specificity and efficacy, accelerating groundbreaking discoveries and therapeutic advancements in immunology and beyond. We are dedicated to meeting your research needs with our expertly curated antibody collection.

    TNF: A Pivotal Target for Inflammatory Disease Therapy

    Tumor Necrosis Factor (TNF) is a master pro-inflammatory cytokine that modulates multiple signaling pathways with wide-ranging downstream effects, playing a vital role in the immune response. Extensive research over 40 years has implicated TNF in numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, ankylosing spondylitis, and Crohn's disease. As a result, understanding TNF's complex signaling processes is critical for creating effective therapies for these chronic diseases.

    Alternative Names

    Tumor necrosis factor; TNF-α; TNF-alpha; TNFA; DIF; TNFSF2; TNLG1F; Tumor necrosis factor alpha.

    Background

    This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020].

    Anti-TNF rAb Products

    Creative Biolabs' anti-TNF recombinant antibodies are engineered with superior precision and affinity, ensuring potent neutralization of TNF activity. Our products offer exceptional batch-to-batch consistency and high purity, critical for reproducible research and reliable therapeutic development. These advanced features contribute to enhanced experimental accuracy and the expedited progression of your projects.

    Table 1. Featured anti-TNF recombinant antibody products at Creative Biolabs.

    Cat. No. Product Name Target Species Host Species Applications
    TAB-034-F(E) Anti-Human TNF alpha Recombinant Antibody Fab Fragment (TAB-034-F(E)) Human Humanized (from mouse) Fab' ELISA, FC, IP, FuncS, IF, Neut, IHC
    TAB-006 Anti-Human TNF Recombinant Antibody (Infliximab) Human Chimeric (mouse/human) IgG1 - kappa IF, IP, Neut, FuncS, ELISA, FC, WB
    TAB-010 Anti-Human TNF Recombinant Antibody (TAB-010) Human Human IgG1, κ WB, FC, IP, ELISA, Neut, FuncS, IF
    ZG-0128C Mouse Anti-TNF Recombinant Antibody (clone Q36) Human, Mouse, Rat Mouse IgG WB, IHC-P, IF
    ZG-0127C Mouse Anti-TNF Recombinant Antibody (clone Q34) Human, Mouse, Rat Mouse IgG WB, IHC-P, IF

    Creative Quality Control

    Our anti-TNF recombinant antibody products undergo rigorous quality control measures, including extensive characterization for purity, binding affinity, and biological activity. We employ state-of-the-art analytical techniques to guarantee that every product meets the highest industry standards, ensuring reliable performance and supporting the integrity of your scientific endeavors.

    Fig.1 WB analysis. (Creative Biolabs Original)Fig.1 WB analysis of anti-TNF antibody
    (Cat# TAB-010, Creative Biolabs).

    Fig.2 ELISA analysis. (Creative Biolabs Original)Fig.2 ELISA analysis of anti-TNF antibody
    (Cat# TAB-010, Creative Biolabs).

    Fig.3 WB analysis. (Creative Biolabs Original)Fig.3 WB analysis of anti-TNF antibody
    (Cat# ZG-0127C, Creative Biolabs).

    Fig.4 IHC analysis. (Creative Biolabs Original)Fig.4 IHC analysis of anti-TNF antibody
    (Cat# ZG-0127C, Creative Biolabs).

    Fig.5 WB analysis. (Creative Biolabs Original)Fig.5 WB analysis of anti-TNF antibody
    (Cat# ZG-0128C, Creative Biolabs).

    Fig.6 IHC analysis. (Creative Biolabs Original)Fig.6 IHC analysis of anti-TNF antibody
    (Cat# ZG-0128C, Creative Biolabs).

    Customer Reviews

    Excellent
    Li***a
    Human Anti-TNF Recombinant Antibody (clone D2E7) (HPAB-A1379-YJ)
    Wow, the anti-TNF recombinant antibody from Creative Biolabs. It has been a complete game changer for our immunological research! Seriously, their stuff is always super pure and active, which means we get awesome, repeatable results every single time. And get this–they deliver fast, and their customer support is just fantastic. Honestly, they're our absolute favorite for all our important research materials!
    17/Nov/2024
    Excellent
    Se***r
    Human Anti-TNF Recombinant Antibody (clone 9C1A) (HPAB-1919-FY)
    Using Creative Biolabs' anti-TNF antibodies in our in vitro assays has significantly improved our experimental outcomes. The specificity of their product is remarkable, reducing off-target effects and providing clear, actionable data. We've seen a noticeable boost in the efficiency and reliability of our research pipeline since incorporating these antibodies.
    21/Oct/2024
    Excellent
    Mi***l
    Anti-TNF alpha Recombinant Antibody (TAB-768) (TAB-768)
    We've successfully applied Creative Biolabs' anti-TNF recombinant antibodies in our therapeutic development programs. Their consistent performance and robust characterization have been instrumental in advancing our understanding of TNF-mediated diseases and validating potential drug candidates. We highly recommend their products for both research and translational applications.
    23/Feb/2025

    rAb Production

    The production of our anti-TNF recombinant antibody products adheres to stringent quality guidelines, utilizing advanced eukaryotic expression systems to ensure optimal folding and post-translational modifications. This sophisticated manufacturing process yields antibodies with high biological activity and purity, tailored for demanding research and therapeutic applications.

    Featured Anti-TNF Recombinant Antibody Production PlatformsFig.7 Milligram-scale. (Creative Biolabs Original)
    Fig.7 Milligram-scale anti-TNF recombinant antibody production.

    Fig.8 Gram-scale. (Creative Biolabs Original)Fig.8 Gram-scale anti-TNF recombinant antibody production.

    rAb Modalities

    Our anti-TNF recombinant antibody products are available in multiple modalities, offering versatility for diverse research and therapeutic approaches.

    Fig.9 TNF antibody production and modalities. (Creative Biolabs Original)Fig.9 Full-length anti-TNF recombinant antibody production and modalities.

    TNF-Targeted Drug Information

    Table 2. Public drug targeting TNF.

    Company Research phase Classification Condition
    Asahi Kasei (Originator) Pre-Registered Polypeptides, from 41 AA
    Recombinant proteins
    Tumor Necrosis Factors     		Cancer
    InKine (Salix)
    Salix (Originator)     		Phase III Crohn's disease
    Thrombocytopenia, immune (Purpura, idiopathic thrombocytopenic)
    Ulcerative colitis
    Abbott (Originator) Phase III Antibody-Derived Binding Proteins Septic shock
    Genentech
    Roche (Originator)     		Phase III Fusion Proteins
    Polypeptides, from 41 AA     		Arthritis
    Multiple sclerosis
    Septic shock
    Bayer (Originator)
    UCB Celltech     		Phase III Monoclonal Antibodies Immunological Disorders
    Septic shock
    Teikyo University (Originator) Phase II Polypeptides, from 41 AA
    Recombinant proteins
    Tumor Necrosis Factor-alpha (TNF-alpha)     		Cancer
    Celgene (Originator) Phase II Crohn's disease
    UCB Celltech (Originator) Phase II Murine Monoclonal Antibodies Septic shock
    Genentech (Originator) Phase II Polypeptides, from 41 AA
    Recombinant proteins
    Tumor Necrosis Factor-alpha (TNF-alpha)     		Cancer
    Infection, viral
    Celgene (Originator) Phase I Inflammatory bowel disease
    Novartis (Originator)
    Novartis Vaccines and Diagnostics (Originator)     		Phase I HIV Vaccines Infection, HIV
    Merck Serono
    Serono (Merck Serono)
    Yeda (Originator)     		Discontinued Arthritis, psoriatic
    Crohn's disease
    Endometriosis
    Multiple sclerosis
    Psoriasis
    Reperfusion lesion

    (Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

    Creative Biolabs is committed to offering new and dependable solutions to the international scientific community. Our extensive portfolio of anti-TNF recombinant antibody products is designed to meet your specific research and development needs. We invite you to explore the full potential of our offerings and encourage you to reach out to us today to discuss how our expertise can support your next breakthrough.

    Related Diseases
    Asthma Asthma
    Inflammatory Bowel Diseases Inflammatory Bowel Diseases
    Related Signaling Pathways
    TNF Signaling Pathway TNF Signaling Pathway
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