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TNF

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This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, Dot, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, FacS, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
IF, FC, Biosensors, FuncS
Species Reactivity:
Human
Type:
Llama VHH
Application:
WB, ELISA, IHC, FC, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, FC, IP, ELISA, Neut, FuncS, IF
Derivation:
Humanized
Species Reactivity:
Human
Type:
VH - VH' - VH
Application:
WB, IP, IF, FuncS, FC, Neut, ELISA
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG1
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Derivation:
Chimeric (mouse/human)
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
IF, IP, Neut, FuncS, ELISA, FC, WB
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab'
Application:
ELISA, FC, IP, FuncS, IF, Neut, IHC
Derivation:
Human
Species Reactivity:
Human
Type:
[V-kappa]2 - Fc
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Mouse
Species Reactivity:
Human
Type:
F(ab')2 - G3 - kappa
Application:
Neut, ELISA, IF, IP, FuncS, FC, ICC
Derivation:
Cow
Species Reactivity:
Human
Type:
Antibody
Targets:
IL17 & TNF
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Targets:
IL17A & TNF
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Targets:
IL-17A & TNF
Type:
DVD-Ig
Application:
FuncS, Promising therapeutic agent
Derivation:
Cow
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Scaffold Name:
10-FnIII
Target:
TNFα
Species Reactivity:
Human
Derivation:
mRNA Display
Scaffold Name:
Kunitz domains
Target:
TNFα
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
Ubiquitin
Target:
TNFα
Derivation:
Phage display
Scaffold Name:
Z-domain of protein A
Target:
TNFα
Species Reactivity:
Human
Derivation:
Phage display
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