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TNF
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Human Anti-TNF Recombinant Antibody (clone A2); Fab Fragment (PFBL-349)
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FuncS
Human Anti-TNF Recombinant Antibody (clone A2); scFv Fragment (PSBL-349)
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FuncS
Human Anti-TNF Recombinant Antibody (clone A2) (PABL-349)
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- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, FuncS
Mouse Anti-TNF Recombinant Antibody (clone 18C3) (MOB-1076z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, FuncS
Anti-Human TNFα/RANKL Therapeutic Antibody Fab Fragment (8G12) (TAB-311CT-F(E))
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human RANKL, Human THFα
- Application: Neut, ELISA, FC
Anti-Human TNFα/RANKL Therapeutic Antibody scFv Fragment (8G12) (TAB-311CT-S(P))
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human RANKL, Human THFα
- Application: Neut, ELISA, FC
Anti-Human TNFα/RANKL Therapeutic Antibody (8G12) (TAB-311CT)
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human RANKL, Human THFα
- Application: Neut, ELISA, FC
Z-domain of protein A scaffold protein anti-Human TNFα (SZA-L241)
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- Scaffold Name: Z-domain of protein A
- Target: TNFα
- Species Reactivity: Human
- Derivation: Phage display
Ubiquitin scaffold protein anti-TNFα (SUB-L209)
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- Scaffold Name: Ubiquitin
- Target: TNFα
- Derivation: Phage display
Anti-Human TNF Therapeutic Antibody (Placulumab) (TAB-254)
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- Derivation: Human
- Species Reactivity: Human
- Type: [V-kappa]2 - Fc
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Kunitz domains scaffold protein anti-Human TNFα (SKD-L116)
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- Scaffold Name: Kunitz domains
- Target: TNFα
- Species Reactivity: Human
- Derivation: Phage display
10-FnIII scaffold protein anti-Human TNFα (SFN-L026)
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- Scaffold Name: 10-FnIII
- Target: TNFα
- Species Reactivity: Human
- Derivation: mRNA Display
Afuco™ Anti-Human TNF ADCC Therapeutic Antibody (AVX-470), ADCC Enhanced (AFC-601CL)
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- Derivation: Cow
- Species Reactivity: Human
- Type: ADCC enhanced antibody
Anti-Human TNF alpha Therapeutic Antibody Fab Fragment (Certolizumab Pegol) (TAB-034-F(E))
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab'
- Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
Anti-Human TNF Therapeutic Antibody (AVX-470) (TAB-623CL)
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- Derivation: Cow
- Species Reactivity: Human
- Type: Antibody
- Application: Neut
Anti-Human TNF Therapeutic Antibody (Adalimumab) (TAB-010)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Anti-Human TNF Therapeutic Antibody (Infliximab) (TAB-006)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Anti-TNFα Therapeutic Antibody (Afelimomab) (TAB-718)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: F(ab')2 - G3 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Anti-Human TNF alpha Therapeutic Antibody (Golimumab) (TAB-062)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Anti-TNF alpha Therapeutic Antibody (Nerelimomab) (TAB-768)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG1
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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