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TNF
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Related Diseases
Asthma
Inflammatory Bowel Diseases
Related Signaling Pathways
TNF Signaling Pathway
Human Anti-TNF Recombinant Antibody (clone A2); Fab Fragment (PFBL-349)
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FuncS
Human Anti-TNF Recombinant Antibody (clone A2); scFv Fragment (PSBL-349)
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FuncS
Human Anti-TNF Recombinant Antibody (clone A2) (PABL-349)
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- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, FuncS
Mouse Anti-TNF Recombinant Antibody (clone 18C3) (MOB-1076z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC, FuncS
Anti-Human TNFα/RANKL Recombinant Antibody Fab Fragment (8G12) (TAB-311CT-F(E))
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human RANKL, Human THFα
- Application: Neut, ELISA, FC
Anti-Human TNFα/RANKL Recombinant Antibody scFv Fragment (8G12) (TAB-311CT-S(P))
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human RANKL, Human THFα
- Application: Neut, ELISA, FC
Anti-Human TNFα/RANKL Recombinant Antibody (8G12) (TAB-311CT)
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human RANKL, Human THFα
- Application: Neut, ELISA, FC
Z-domain of protein A scaffold protein anti-Human TNFα (SZA-L241)
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- Scaffold Name: Z-domain of protein A
- Target: TNFα
- Species Reactivity: Human
- Derivation: Phage display
Ubiquitin scaffold protein anti-TNFα (SUB-L209)
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- Scaffold Name: Ubiquitin
- Target: TNFα
- Derivation: Phage display
Anti-Human TNF Recombinant Antibody (Placulumab) (TAB-254)
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- Derivation: Human
- Species Reactivity: Human
- Type: [V-kappa]2 - Fc
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Kunitz domains scaffold protein anti-Human TNFα (SKD-L116)
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- Scaffold Name: Kunitz domains
- Target: TNFα
- Species Reactivity: Human
- Derivation: Phage display
Afuco™ Anti-Human TNF ADCC Recombinant Antibody (AVX-470), ADCC Enhanced (AFC-601CL)
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- Derivation: Cow
- Species Reactivity: Human
- Type: ADCC enhanced antibody
10-FnIII scaffold protein anti-Human TNFα (SFN-L026)
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- Scaffold Name: 10-FnIII
- Target: TNFα
- Species Reactivity: Human
- Derivation: mRNA Display
Bovine Anti-TNF Recombinant Antibody (TAB-623CL) (TAB-623CL)
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- Species Reactivity: Human
- Type: Bovine IgG
- Application: Neut
Anti-Human TNF alpha Recombinant Antibody Fab Fragment (Certolizumab Pegol) (TAB-034-F(E))
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Fab'
- Application: ELISA, FC, IP, FuncS, IF, Neut, IHC
Anti-Human TNF Recombinant Antibody (Infliximab) (TAB-006)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Anti-Human TNF Recombinant Antibody (TAB-010) (TAB-010)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1, κ
- Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Anti-TNFα Recombinant Antibody (Afelimomab) (TAB-718)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: F(ab')2 - G3 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Anti-Human TNF alpha Recombinant Antibody (Golimumab) (TAB-062)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Anti-TNF alpha Recombinant Antibody (Nerelimomab) (TAB-768)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG1
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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