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    Anti-TNFSF15 Recombinant Antibody Products

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    Anti-TNFSF15 Products

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    For Research Use Only. Not For Clinical Use.


    Creative Biolabs is dedicated to providing the whole world’s highest quality, innovative anti-TL1A antibodies to accelerate biological understanding of target TL1A.

    TL1A: A Key Target in Inflammatory Autoimmune Diseases

    TL1A (TNF superfamily member 15) is a member of the tumor necrosis factor family. TL1A participates in innate and adaptive immune homeostasis by binding to its receptor death receptor 3 (DR3). It was involved in the development and pathogenesis of autoimmune diseases, including inflammatory bowel disease, psoriasis, and rheumatoid arthritis. Based on the above, it is warranted to implement thorough functional studies for target TL1A and it may provide evidence for the future clinical treatment of autoimmune diseases.

    Alternative Names

    Tumor necrosis factor (ligand) superfamily; member 15; TL1; TL1A; VEGI; VEGI192A; tumor necrosis factor ligand superfamily member 15; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor-192A

    Background

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene.
    Protein class

    Human disease related genes

    Predicted location

    Intracellular, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Glandular and luminal cells, Basal respiratory cells, Endometrial ciliated cells, Basal squamous epithelial cells, Squamous epithelial cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced

    Interaction

    Homotrimer.

    Molecular function

    Cytokine

    More Types Infomation

    Anti-TL1A Recombinant Antibody Products

    We provided the high-quality anti-TL1A recombinant antibody products to accelerate biological research of TL1A targets.

    Cat. No. Product Name Target Species Host Species Applications
    TAB-334CQ Mouse Anti-TL1A Recombinant Antibody Human Mouse ELISA
    TAB-345CQ Human Anti-TL1A Recombinant Antibody Human; Cynomolgus monkey; Mouse Human ELISA; FC; Neut
    HPAB-0457-WJ Human Anti-TL1A Recombinant Antibody Human Humanized ELISA; Neut; FuncS
    HPAB-0011-WJ Human Anti-TL1A Recombinant Antibody Human Human ELISA; Neut
    HPAB-N0287-YC Mouse Anti-TL1A Recombinant Antibody Human; Mouse Mouse Inhib; Neut

    Creative Quality Control

    To meet customer requirements, we have established a stringent quality management system to ensure our product quality and provide customers with high-quality technical services.

    Fig.1 SDS-PAGE analysis of TAB-334CQ. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-TL1A antibody (Cat#TAB-334CQ, Creative Biolabs).

    Fig.2 SEC-HPLC analysis of TAB-334CQ. (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-TL1A antibody (Cat# TAB-334CQ, Creative Biolabs).

    Fig.3 ELISA analysis of TAB-334CQ. (Creative Biolabs Original)Fig.3 ELISA analysis of anti-TL1A antibody (Cat#TAB-334CQ, Creative Biolabs).

    Fig.4 WB analysis of TAB-334CQ. (Creative Biolabs Original)Fig.4 WB analysis of anti-TL1A antibody (Cat#TAB-334CQ, Creative Biolabs).

    Customer Reviews

    Excellent
    Va**r
    Mouse Anti-TL1A Recombinant Antibody (Cat#: TAB-334CQ)
    This anti-TL1A recombinant mouse antibody was used to test the expression of protein TL1A in serum from the infected mice. Following the correct process and the concentration ratio recommended by the company, we detected a satisfactory positive result.
    19/Oct/2023
    Excellent
    Al**n
    Human Anti-TL1A Recombinant Antibody (Cat#: TAB-345CQ)
    This Human Anti-TL1A Recombinant Antibody (TAB-345CQ) was used to detect the level and distribution of TL1A in different tissues and cells. This antibody has played a crucial role in my research. It allows me to precisely measure the expression of TL1A and investigate its involvement in inflammatory and immune processes. The high affinity and selectivity of this antibody ensure the accuracy and reproducibility of my experiments, providing valuable insights into the mechanisms related to TL1A and opening up new possibilities for therapeutic strategies.
    7/Jul/2023
    Excellent
    Th**esa
    Human Anti-TL1A Recombinant Antibody (Cat#: HPAB-0457-WJ)
    I acquired the Human Anti-TL1A Recombinant Antibody (HPAB-0457-WJ) to detect TL1A in specific samples. This antibody has proven to be highly valuable. Its remarkable neutralizing effect is key. It effectively neutralizes the activity of TL1A, allowing me to precisely study its functions in various biological processes. This has greatly facilitated my research and provided crucial insights for potential therapeutic applications.
    14/Mar/2024

    Anti-TL1A Recombinant Antibody Production

    We have years of experience in recombinant antibody production and optimization. With the best quality service, we provide you with recombinant antibody products with high quality and high level in the shortest time.

    Featured Anti-TL1A Recombinant Antibody Production Platforms Fig.5 Anti-TL1A recombinant antibody production: milligram-scale. (Creative Biolabs Original)
    Fig.5 Milligram-scale recombinant antibody production.

    Fig.6 Anti-TL1A recombinant antibody production: gram-scale. (Creative Biolabs Original)Fig.6 Gram-scale recombinant antibody production

    Anti-TL1A Recombinant Antibody Modalities

    Creative Biolabs has multiple high-quanlity antibody formats in order to meet the customers’ diverse demands. The antibody format includes but is not limited to full length, VH, Fab, scFv, scFv-Fc, scFv-CH3, etc.

    Fig.7 Diverse anti-TL1A recombinant antibody production and modalities. (Creative Biolabs Original)Fig.7 Full Length Anti-TL1A Recombinant Antibody Production and Modalities

    TL1A-Targeted Drug Information

    Table 1. Therapeutic approaches targeting TL1A in clinical development.

    Research phase Company Classification Indications Details
    Phase III Merck & Co (Originator)
    Prometheus Biosciences     		Humanized Monoclonal Antibody Crohn's disease T***ok**art is a humanized monoclonal antibody under research and might be used for the treatment of Crohn's disease.
    Phase II Telavant Human Monoclonal Antibody Crohn's disease P*-06***605 is a human monoclonal  antibody being researched and could potentially be utilized for the treatment of Crohn's disease.
    Phase II Teva Human Monoclonal Antibody

    Asthma

    		T*V-4**74 is a human monoclonal antibody under research and might be used for the treatment of Asthma.
    Phase I Pfizer Biological Product Inflammatory bowel disease P*-072**271 is a biological product being researched and could potentially be utilized for the treatment of Inflammatory bowel disease.
    Preclinical FutureGen Human Monoclonal Antibody Inflammatory bowel disease F*-M*01 is a human antibody under research and might be used for the treatment of Inflammatory bowel disease.
    Preclinical Pelican Therapeutics Fusion Proteins Polypeptides Asthma; Autoimmune disease; Inflammatory disorders P**-15 is a biological product being researched and could potentially be utilized for the treatment of Asthma, Autoimmune disease and Inflammatory disorders.
    Preclinical Spyre Therapeutics Monoclonal Antibody Inflammatory bowel disease S*Y-002 is a monoclonal antibody being researched and could potentially be utilized for the treatment of Inflammatory bowel disease.

    For additional information about anti-TL1A recombinant antibody products, please feel at ease to contact us. We are looking forward to forming a beneficial partnership with you.

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