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    TNFSF18

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
    Predicted location

    Intracellular

    Single cell type specificity

    Group enriched (Basal squamous epithelial cells, Hofbauer cells, Squamous epithelial cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (EFO-21, HUVEC TERT2, TIME)

    Interaction

    Homodimer (By similarity). Homotrimer.

    Molecular function

    Cytokine

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