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TOP3A
Loading...Anti-TOP3A Products
- Rabbit Anti-TOP3A Polyclonal Antibody (MRO-2236-CN) (MRO-2236-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IF, IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Binds ssDNA (PubMed:29290614). Interacts (via N-terminal region) with BLM; the interaction is direct. Directly interacts with RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.
Molecular function
DNA-binding, Isomerase, Topoisomerase
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