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TPPP

Anti-TPPP Products

Rabbit Anti-TPPP Recombinant Antibody (clone JE47-35) (VS3-WK375)
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
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Rabbit Anti-TPPP Recombinant Antibody (clone R06-8I4) (VS3-FY1920)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF
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CytoStream™ Rabbit Anti-TPPP Recombinant Antibody (VS13-YC1182) (VS13-YC1182)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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Anti-TPPP Immunohistochemistry Kit (VS-0325-XY2339)
- Species Reactivity: Human, Mouse, Rat
- Target: TPPP
- Application: IHC
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Rabbit Anti-TPPP Recombinant Antibody (clone DS3660AB) (MOR-3660)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP, IHC
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For Research Use Only. Not For Clinical Use.

TPPP (Tubulin Polymerization Promoting Protein) is a Protein Coding gene. Diseases associated with TPPP include Lymphoid Interstitial Pneumonia and Dementia, Lewy Body. Among its related pathways are Glial Cell Differentiation and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include microtubule binding and tubulin binding. An important paralog of this gene is TPPP3.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Excitatory neurons, Horizontal cells, Alveolar cells type 1, Inhibitory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A549, AN3-CA, SCLC-21H)

Interaction

Homodimer (PubMed:17693641, PubMed:22484033, PubMed:26289831, PubMed:33831707). Binds tubulin; binding is inhibited by GTP (PubMed:17105200, PubMed:26289831). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct (PubMed:18028908, PubMed:22328514). Interacts with LIMK2 (PubMed:22328514). Interacts with HDAC6; thereby inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Interacts with aggregated SNCA; may have a pro-aggregatory role in synucleinopathies (PubMed:15590652, PubMed:17027006). Interacts with DYNLL1 (PubMed:31505170). Interacts (via C-terminus) with S100A2, S100A6 and S100B; these interactions inhibit TPPP dimerization (PubMed:33831707).

Molecular function

Hydrolase

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