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TSPAN8

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.
Protein class

Cancer-related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Paneth cells, Distal enterocytes, Undifferentiated cells, Ductal cells, Intestinal goblet cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (OE19)

More Types Infomation

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